发明名称 |
SHORT INTERFERING RNA, SHORT HAIRPIN RNA AND CODING VECTORS THEREOF, RELATED COMPOSITIONS AND USE THEREOF USED FOR INHIBITING INFLUENZA VIRUS INFECTION |
摘要 |
The present invention provides compositions comprising an RNAi-inducing entity any of a variety of different delivery agents. Preferred RNAi-inducing agents include siRNA, shRNA, and RNAi-inducing vectors. Preferred delivery agents include cationic polymers, modified cationic polymers, lipids, and surfactants suitable for introduction into the lung. The invention further provides methods of inhibiting expression of a target transcript in a mammal and methods of treating or preventing a disease or condition in a mammal by administration of the compositions. |
申请公布号 |
HK1104302(A1) |
申请公布日期 |
2012.07.27 |
申请号 |
HK20070112757 |
申请日期 |
2007.11.22 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
CHEN, JIANZHU;EISEN, HERMAN, N.;GE, QING |
分类号 |
A61K;A61K38/00;A61K48/00;C07H;C12N;C12N15/11;C12N15/113;C12Q |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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