NEUROPROTECTION USING NAP-LIKE AND SAL-LIKE PEPTIDE MIMETICS

摘要

Disclosed is a peptide mimetic, wherein the peptide mimetic has neuroprotective activity and has the formula (R1)a-(R2)- (R3)b wherein: R1 is an amino acid sequence comprising from 1 to about 40 amino acids wherein each amino acid is independently selected from the group consisting of naturally occurring amino acids and amino acid analogs; R2 is NATLSIHQ (SEQ ID NO:4); R3 is an amino acid sequence comprising from 1 to about 40 amino acids wherein each amino acid is independently selected from the group consisting of naturally occurring amino acids and amino acid analogs; and a and b are independently selected and are equal to zero or one, with the proviso that the peptide mimetic does not comprise the sequence NAPVSIPQ (SEQ ID NO:1) or SALLRSIPA (SEQ ID NO:19).