| 摘要 |
FIELD: medicine. ^ SUBSTANCE: there are offered: recovered polynucleotides and polypeptides for binding human EGFR as a part of an antibody, a vector and a host cell for antibody expression, a method for producing an anti-EGFR antibody and an antibody fragment, the anti-EGFR antibody and the antibody fragment. There are discussed a composition containing the anti-EGFR antibody or its fragment, as well as applying the antibody and its fragment for treating EGFR-associated disorders. Besides, there are described versions of glycosylation of the anti-EGFR antibody or its fragment. ^ EFFECT: invention can find further application in therapy of various EGFR-mediated diseases. ^ 30 cl, 6 ex, 32 dwg, 39 tbl |
