Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor

摘要

A process for preparing a compound having structural formula (1*), wherein the substituents are as defined in the specification is disclosed, wherein process (1) is a process comprising, in toto, the steps of: (a) treating a compound of formula (XII) with trichloroacetyl chloride and triethylamine in dichloromethane to provide a compound of formula (la); and (b) treating the compound of formula (la) with a compound formula (XIII) (shown in the specification) and 1,8-diazabicycloundec-7-ene (DBU) in acetonitrile to provide a compound of formula (1*). Also disclosed are alternate processes for preparing a compound of formula (1*). These compounds of formula (1*) inhibit the VR1 receptor in mammals and are useful for controlling pain.