Azacarboline derivatives, preparation thereof, and therapeutic use thereof as kinase inhibitors

摘要

Disclosed herein are alpha-aza-beta-carboline derivatives of formula (I), defined by 1,7-diazacarbazole, 8-aza-beta-carboline or 9H-pyrrolo[2,3-b:5,4-c']dipyridine derivatives. Additionally disclosed are methods of preparation thereof, including key coupling reactions, such as Suzuki and Stille reactions, and cyclisation reactions, such as Buchwald-Hartwig and copper-catalysed cyclisations. Additionally disclosed is the use thereof in the treatment of cancer, chemotherapy, specifically relating to Pim kinase deregulation/inhibition.