CARVEDILOL FREE BASE, CARVEDILOL SALT, ANHYDROUS FORM OR SOLVATE THEREOF, CORRESPONDING PHARMACEUTICAL COMPOSITION, CONTROLLED RELEASE FORMULATION, AND TREATMENT OR DELIVERY METHOD

摘要

PROBLEM TO BE SOLVED: To provide carvedilol free base, carvedilol salts, anhydrous forms, or solvates thereof, corresponding pharmaceutical compositions or controlled release formulations, and methods delivery of carvedilol forms to a gastrointestinal tract.

SOLUTION: The controlled release formulation comprises a solubility-enhanced carvedilol free base or carvedilol salt, solvate or anhydrous form thereof, wherein the controlled release formulation following oral dosage exhibits a substantially biphasic plasma profile with a first plasma concentration peak level within 1-4 hours of ingestion and a second plasma concentration peak level within 5-10 hours after ingestion.

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