| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide transdermal dosage forms which are useful for preventing or discouraging tampering, abuse, misuse or diversion of a dosage form. <P>SOLUTION: The transdermal dosage form comprises an active agent component comprising an active agent dispersed in a polymeric material. The transdermal dosage form comprises: the active agent component having a proximal skin-contacting surface, a distal surface, and at least one channel passing between the proximal and distal surfaces; an adverse agent component comprising an antagonist to the active agent; and a barrier interposed between the distal surface of the active agent component and the adverse agent component. The barrier is permeable to a solvent selected from the group consisting of water, ethanol, ether, and mixtures thereof, and further, the barrier is impermeable to diffusion of an active agent and an adverse agent in the absence of the solvent. <P>COPYRIGHT: (C)2012,JPO&INPIT |
