发明名称 |
SUPERIOR EFFICACY OF CD37 ANTIBODIES IN CLL BLOOD SAMPLES |
摘要 |
The present invention describes CD37 antibodies, especially A2 and B2, for the treatment of patients with CLL, especially of patients belonging to a“high risk”or“ultra-high risk”group of patients. Those patients are either patients who are refractory to fludarabine treatment or patients who carry a genetic marker which is indicative for poor prognosis or increased risk of treatment failure, e.g. patients with TP53 dysfunction or deletion of chromosome 17p13, or patients after failure to previous anti-CD20 treatment. The ability of A2 and B2 to deplete CLL cells is high both in patient samples derived from patients with normal risk and with increased risk (“high risk”patients) and clearly superior to that of rituximab and alemtuzumab.
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申请公布号 |
US2012189618(A1) |
申请公布日期 |
2012.07.26 |
申请号 |
US201113182471 |
申请日期 |
2011.07.14 |
申请人 |
STILGENBAUER STEPHAN;ZENZ THORSTEN;HEIDER KARL-HEINZ;BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
STILGENBAUER STEPHAN;ZENZ THORSTEN;HEIDER KARL-HEINZ |
分类号 |
A61K39/395;A61P35/00;A61P35/02;C12N5/071 |
主分类号 |
A61K39/395 |
代理机构 |
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