发明名称 |
HOMOMULTIMERIC STRUCTURE BY ASSEMBLY OF SIRV2 P98 PROTEINS OR P98 VARIANTS, CONJUGATE AND USES THEREOF |
摘要 |
The present invention relates to a homomultimeric protein structure constituted by assembled monomers of the P98 protein of Sulfolobus islandicus rod-shaped virus 2 (SIRV2) or assembled monomer variants of said P98 protein. In a particular embodiment, this homomultimeric protein structure has a seven-fold rotational symmetry, and is found in an open conformation or closed conformation. A particular structure has the form of baseless 7-face pyramid. The invention also relates to a conjugate comprising or consisting of a homomultimeric protein structure of the invention to which one or more heterologous molecule(s) is attached. Furthermore, the invention also concerns a homomultimeric protein structure or a conjugate of the invention, inserted into or exposed at the surface of a lipid layer or bilayer, of a vesicle or of a cell, and their uses thereof. |
申请公布号 |
WO2012098243(A1) |
申请公布日期 |
2012.07.26 |
申请号 |
WO2012EP50902 |
申请日期 |
2012.01.20 |
申请人 |
INSTITUT PASTEUR;UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6);UNIVERSITE PARIS-SUD 11;QUAX, TESSA E.F.;LUCAS, SOIZICK;FORTERRE, PATRICK;PRANGISHVILI, DAVID |
发明人 |
QUAX, TESSA E.F.;LUCAS, SOIZICK;FORTERRE, PATRICK;PRANGISHVILI, DAVID |
分类号 |
C07K14/01;B82Y5/00 |
主分类号 |
C07K14/01 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|