| 摘要 |
The present invention relates generally to newly discovered S/MAR elements useful in expression vectors. In particular, the present invention relates to the use of the MUR-region of CMV as S/MAR element in expression vectors. In another aspect, the present invention relates to vector nucleic acids containing the same as well as host or host cells containing said vector nucleic acids either stably integrated into the host genome or episomally replicating, or alternatively, present as a minicircle expression vector for stable or a transient expression. In another aspect, the present invention relates to a method for the production of a molecule of interest based on the MUR-region of CMV as a S/MAR region as well as kits or systems containing the vector nucleic acid or cell or cell line according to the present invention. |
