ARYLOXY PHENOXY ACRYLIC COMPOUND HAVING HIF-1 INHIBITION ACTIVITY, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ACTIVE INGREDIENT

摘要

The present invention relates to a compound having HIF-1 inhibition activity, to a method for preparing same, and to a pharmaceutical composition containing same as an active ingredient. The compound of the present invention exhibits anticancer activity by inhibiting the activity of HIF-1, which is a transcription factor that plays a significant role in cancer cell growth and metastasis, and does not indicate non-selective, cytotoxic anti-tumour activity. Accordingly, the compound or a pharmaceutically acceptable salt thereof according to the present invention inhibits HIF-1 activity, and therefore can be used as a therapeutic agent for solid tumours such as colon cancer, liver cancer, stomach cancer and breast cancer. In addition, the compound or the pharmaceutically acceptable salt thereof according to the present invention can be used as an active ingredient for a therapeutic agent for diabetic retinopathy or arthritis which may become worse when hypoxia-induced VEGF expression by HIF-1 increases.