IMMUNE RESPONSE INHIBITING COMPOSITION CONTAINING STEM CELLS EXPRESSING TRYPTOPHAN METABOLIZING ENZYME GENES

摘要

The present invention relates to mesenchymal stem cells expressing tryptophan metabolizing enzyme genes and to an immune inhibiting composition comprising the same. More particularly, kynurenine-3-hydroxylase and kynureninase which are tryptophan metabolizing enzymes which are not naturally expressed from mesenchymal stem cells are expressed in mesenchymal stem cells, to thereby effectively inhibit alloantigen-reactive T cells of mesenchymal stem cells and thus increase immunosuppressive effects. The mesenchymal stem cells in which kynurenine-3-hydroxylase and kynureninase are expressed may provide more enhanced immunosuppressive effects than mesenchymal stem cells in which those enzymes are not expressed, and therefore, may effectively prevent and treat diseases caused by T-cell overactivation, including graft-versus-host diseases.