AQUEOUS PHARMACEUTICAL COMPOSITION OF 2,6-DIISOPROPYLPHENOL (PROPOFOL) AND ITS USE

摘要

PROBLEM TO BE SOLVED: To provide aqueous pharmaceutical compositions containing a lipophilic therapeutic agent.

SOLUTION: The aqueous pharmaceutical compositions contains the compound 2,6-diisopropylphenol (propofol). Preferred compositions contain propofol in the presence of at least one block copolymer (for example, P188 or another poloxamer) and a polyethylene glycol (PEG). The compositions are preferably sterile or are readily sterilized (e.g., by autoclaving) and are suitable for parenteral administration to any animal, including humans. The compositions are also chemically and physically stable over a wide range of environmental conditions and for extended periods of time.

COPYRIGHT: (C)2012,JPO&INPIT