摘要 |
E. coli proteins have been identified that are useful as carrier proteins to improve a response to a polysaccharide immunogen conjugated to such protein. In particular, AcfD precursor protein (orf3526 polypeptide), Flu antigen 43 protein (orf1364 polypeptide), and Sell repeat-containing protein (upec-5211 polypeptide) have been shown to be effective. Additionally, these E. coli proteins can enhance the immune response to glucans, particularly fungal glucans. |
申请人 |
NOVARTIS AG;COSTANTINO, PAOLO;SERINO, LAURA;ROMANO, MARIA, ROSARIA;TONTINI, MARTA;BERTI, FRANCESCO;MICOLI, FRANCESCA;KABANOVA, ANNA |
发明人 |
COSTANTINO, PAOLO;SERINO, LAURA;ROMANO, MARIA, ROSARIA;TONTINI, MARTA;BERTI, FRANCESCO;MICOLI, FRANCESCA;KABANOVA, ANNA |