INFLUENZA VACCINE INCLUDING COMBINATION OF PARTICULATE ADJUVANT AND IMMUNOPOTENTIATOR

摘要

PROBLEM TO BE SOLVED: To provide influenza vaccines including combinations of particulate adjuvants and immunopotentiators.

SOLUTION: Influenza vaccines containing insoluble particulate adjuvants have been found to elicit an IgG response that is primarily a TH2 response (IgG1). This response can be shifted towards a TH1 response (IgG2a) by including immunopotentiators in the compositions. Thus the invention provides an immunogenic composition combining: (i) an influenza virus antigen; (ii) an insoluble particulate adjuvant; and (iii) an immunopotentiator. The invention also provides a method for preparing the immunogenic composition comprising the steps of combining: (i) an influenza virus antigen; (ii) an insoluble particulate adjuvant; and (iii) an immunopotentiator.

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