发明名称 |
TARGETING NAD BIOSYNTHESIS IN BACTERIAL PATHOGENS |
摘要 |
The emergence of multidrug-resistant pathogens necessitates the search for new antibiotics acting on previously unexplored targets. Nicotinate mononucleotide adenylyltransferase of the NadD family, an essential enzyme of NAD biosynthesis in most bacteria, was selected as a target for structure-based inhibitor development. To this end, the inventors have identified small molecule compounds that inhibit bacterial target enzymes by interacting with a novel inhibitory binding site on the enzyme while having no effect on functionally equivalent human enzymes. |
申请公布号 |
US2012190708(A1) |
申请公布日期 |
2012.07.26 |
申请号 |
US201013383340 |
申请日期 |
2010.07.12 |
申请人 |
MACKERELL, JR. ALEXANDER;ZHANG HONG;OSTERMAN ANDREI;KOLHATKAR ROHIT;UNIVERSITY OF MARYLAND, BALTIMORE;THE BOARD OF REGENTS OF THE UNIVERSITY OF THE UNIVERSITY OF TEXAS SYSTEM;SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE |
发明人 |
MACKERELL, JR. ALEXANDER;ZHANG HONG;OSTERMAN ANDREI;KOLHATKAR ROHIT |
分类号 |
A61K31/4365;A61K31/165;A61K31/197;A61K31/404;A61P31/04 |
主分类号 |
A61K31/4365 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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