REPLICATION DEFICIENT ADENOVIRAL TNF VECTOR

摘要

PROBLEM TO BE SOLVED: To provide replication deficient TNF adenoviral vectors that have greater flexibility in their construction and use, and can provide greater success in the treatment of a tumor or cancer.

SOLUTION: There is provided an adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region 12 of the adenoviral genome, (b) a nucleic acid sequence 15 encoding TNF, and (c) a radiation inducible promoter 14 operably linked to the nucleic acid sequence 15 encoding TNF. The invention also provides an adenoviral vector comprising a spacer element 18 of at least 15 base pairs in the E4 region 12 of the adenoviral genome. A method for producing the adenoviral vector and a method for treating a tumor or cancer in a host comprising administering an anti-cancer or anti-tumor effective amount of the adenoviral vector are also provided.

COPYRIGHT: (C)2012,JPO&INPIT