发明名称 |
PREPARATION OF ISOLATED AGONIST ANTI-EDAR MONOCLONAL ANTIBODIES |
摘要 |
The present invention concerns the preparation of substantially purified agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. The invention further relates to isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof as well as their use in the treatment of X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. The invention also relates to a pharmaceutical composition comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof and to a method of treating X-linked hypohidrotic ectodermal dysplasia and tooth agenesis. Finally, the present invention concerns a pharmaceutical kit comprising said isolated agonist anti-EDAR monoclonal antibodies or isolated monoclonal antibody fragments or antigen binding portions or fragments thereof. |
申请公布号 |
US2012192296(A1) |
申请公布日期 |
2012.07.26 |
申请号 |
US201013260937 |
申请日期 |
2010.03.30 |
申请人 |
SCHNEIDER PASCAL;DUNKEL NATHALIE;DEMOTZ STEPHANE;UNIVERSITE DE LAUSANNE;EDIMER BIOTECH S.A. |
发明人 |
SCHNEIDER PASCAL;DUNKEL NATHALIE;DEMOTZ STEPHANE |
分类号 |
A01K67/027;A61K39/395;A61P1/02;A61P11/00;A61P17/00;A61P17/14;A61P43/00;C07K16/24;C07K19/00;C12N1/19;C12N1/21;C12N5/10;C12N5/16;C12N15/13;C12N15/63;G01N33/566 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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