PYRROLOTHIAZOLE CONTAINING CURCUMIN COMPOUNDS

摘要

Accordingly, the invention discloses compounds of pyrrolothiazole moiety containing with mono bis substituted curcumin molecules which improves solubility of curcumin. The invention also discloses the method in synthesizing these compounds wherein the steps includes mixing curcumin, isatin derivatives or ninhydrin and thioproline (thiazolidine-4-carboxylic acid) in 20 mL methanol. The mixture was then refiuxed with a solvent on a water bath and excess solvent was removed under vacuum. The residue subjected to flash column chromatography using petroleum ether: ethyl acetate mixture (4:1) as eluent to afford the product. The ratio for curcumin: isatin derivative/ninhydrin:thioproline (thiazolidine-4-carboxylic acid) is 1:1:2 and 1:2:4.