发明名称 |
SYNERGISTIC ANTI-CD47 THERAPY FOR HEMATOLOGIC CANCERS |
摘要 |
<p>Methods are provided for treatment of hematologic cancers, particularly lymphomas and leukemias, including without limitation myelogenous and lymphocytic leukemias. A combination of antibodies specific for CD47; and specific for a cancer associated cell surface marker are administered to the patient, and provide for a synergistic decrease in cancer cell burden. The combination of antibodies may comprise a plurality of monospecific antibodies, or a bispecific or multispecific antibody. Markers of interest include without limitation, CD20, CD22, CD52, CD33; CD96; CD44; CD123; CD97; CD99; PTHR2; and HAVCR2.</p> |
申请公布号 |
EP2477648(A1) |
申请公布日期 |
2012.07.25 |
申请号 |
EP20100817793 |
申请日期 |
2010.09.15 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
WEISSMAN, IRVING L.;MAJETI, RAVINDRA;ALIZADEH, ARASH ASH;CHAO, MARK P. |
分类号 |
A61K39/00;C07K16/28;C12P21/08 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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