| 摘要 |
A method of preparing an extract from Senna leaves (Cassia Angustifolia) comprises reduction of the particle size of the Senna leaves, extraction with subcritical water and then removing the water to produce a pharmaceutically acceptable extract. The extraction may be conducted at 150-230°C and/or 15-100 bar. The water may be removed by evaporation, freeze drying or spray drying. The extract may be formulated in a self emulsifying drug delivery system (e.g. using lauroyl macrogolglycerides and a surfactant) to improve the oral bioavailability of the active constituents; it may be formulated in a topical vehicle (e.g. using cetostearyl alcohol, macrogol cetostearyl ether, liquid paraffin, parabens, water and propylene glycol). The extract may be similar to the corresponding methanolic extract. Extraction of Valerian, Rosemary, German Chamomile and Ginger root is also disclosed. |
