A method and apparatus for obtaining segmented images of the stained regions may comprise quantifying the extent of the presence of staining of a biomarker in an original image of a sample, which may comprise selecting a domain swatch of data based upon a user specified domain knowledge; clustering the data within the original image by conducting a frequency weighted mean shift of the data within the original image to convergence, forming a hierarchical plurality of layers each having a different data resolution to form a hierarchical data pyramid; segmenting the plurality of mean shifted data images to determine in each mean shifted data image within the hierarchical data pyramid data not excluded as outside of the swatch; mapping the data not excluded as outside the swatch spatially back to the original image to create a final image; and, storing the final image on a storage medium for further analysis.
申请公布号
EP2478356(A1)
申请公布日期
2012.07.25
申请号
EP20100817567
申请日期
2010.09.17
申请人
RUTGERS, THE STATE UNIVERSITY;JANOWCZYK, ANDREW;CHANDRAN, SHARAT;MADABHUSHI, ANANT