发明名称 ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS
摘要 or a pharmaceutically suitable salt thereof, wherein, R1 and R2 independently are hydrogen, deuterium, aryl, hetero aryl, C1-C8 alkyl, optionally being substituted with one or more substituents independently being R3, R3 is an aryl, hetero aryl, fluorine(s), a C1-C6 alkyl containing one or more fluorine, a C1-C6 alkyl containing one or more deuterium, a C1-C6 alkyl containing hydroxy, the aryl and heteroaryl optionally being substituted with one or more halogen, a fluorinated alkoxy, a fluorinated alkyl, a sulfonyl, one or more deuterium, a C1-6 alkyl, a C1-6 alkoxy, a nitrile, or R3 is a C1-6 alkyl optionally substituted with one or more of the following groups: COOR4, OCOR4, CONR5R6, NR5COR6, OR4; wherein, R4 is a C1-10 alkyl optionally substituted with one or more fluorine, deuterium, alkoxy, arylcarboxylate, alkyl carboxylate; R5 and R6 are independently selected from hydrogen, alkyl or they may together form a 4-8 membered carbon ring; or R1 and R2 form a 3-10 membered carbon ring optionally comprising O or N and optionally substituted with a C1-10 alkyl or aryl, hetero aryl optionally substituted with R3.
申请公布号 ZA201108119(B) 申请公布日期 2012.07.25
申请号 ZA20110008119 申请日期 2011.11.04
申请人 ASTRAZENECA AB 发明人 BOSTROM JONAS;FEX TOMAS;PETTERSEN DANIEL;CHENG LEIFENG;KARLE MICHAEL;SCHELL PETER
分类号 A61K;A61P;C07D 主分类号 A61K
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