SUBSTITUTED HETEROARYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME
摘要
<p>Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.</p>
申请公布号
EP2477492(A1)
申请公布日期
2012.07.25
申请号
EP20100817928
申请日期
2010.09.17
申请人
VANDERBILT UNIVERSITY
发明人
CONN, JEFFREY P.;LINDSLEY, CRAIG W.;EMMITTE, KYLE A.;WEAVER, CHARLES DAVID;RODRIGUEZ, ALICE, L.;FELTS, ANDREW S.;JONES, CARRIE K.;BATES, BRITTNEY S.