发明名称 |
Human metabolic models and methods |
摘要 |
The invention provides in silico models for determining the physiological function of human cells, including human skeletal muscle cells. The models include a data structure relating a plurality of Homo sapiens reactants to a plurality of Homo sapiens reactions, a constraint set for the plurality of Homo sapiens reactions, and commands for determining a distribution of flux through the reactions that is predictive of a Homo sapiens physiological function. A model of the invention can further include a gene database containing information characterizing the associated gene or genes. A regulated Homo sapiens reaction can be represented in a model of the invention by including a variable constraint for the regulated reaction. The invention further provides methods for making an in silico Homo sapiens model and methods for determining a Homo sapiens physiological function using a model of the invention. |
申请公布号 |
US8229673(B2) |
申请公布日期 |
2012.07.24 |
申请号 |
US20030402854 |
申请日期 |
2003.03.27 |
申请人 |
PALSSON BORNHARD O.;FAMILI IMANDOKHT;COVERT MARKUS W.;SCHILLING CHRISTOPHE H.;GENOMATICA, INC. |
发明人 |
PALSSON BORNHARD O.;FAMILI IMANDOKHT;COVERT MARKUS W.;SCHILLING CHRISTOPHE H. |
分类号 |
C12Q1/00;G01N33/50;C12Q1/68;G01N33/48;G06F19/12;G06F19/28 |
主分类号 |
C12Q1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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