| 发明名称 |
Oligodeoxynucleotide and its use to induce an immune response |
| 摘要 |
D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5′X1X2X3Pu1Py2CpGPu3Py4X4X5X6(W)M(G)N-3′ wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided. |
| 申请公布号 |
US8227446(B2) |
申请公布日期 |
2012.07.24 |
| 申请号 |
US201113104918 |
申请日期 |
2011.05.10 |
| 申请人 |
KLINMAN DENNIS;VERTHELYI DANIELA;ISHII KEN;MOND JAMES J.;GURSEL MAYDA;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMANSERVICES |
发明人 |
KLINMAN DENNIS;VERTHELYI DANIELA;ISHII KEN;MOND JAMES J.;GURSEL MAYDA |
| 分类号 |
A61K39/00;A01N43/04;A61K9/127;A61K31/70;A61K31/7088;A61K39/008;A61K39/38;A61K39/39;A61K45/00;A61K47/00;A61K48/00;C07H21/04 |
主分类号 |
A61K39/00 |
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