| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: present invention refers to a new aliskiren and orotic acid salt, preparing and using it, pharmaceutical preparations containing said salt. The aliskiren and orotic acid salt is used to produce a drug preparation used for preventing and treating diseases or conditions which respond to treatment by renin inhibition. A method for preparing the aliskiren and orotic acid salt consists in the fact that (1) aliskiren in the form of a free base and orotic acid are dissolved in an organic solvent, (2) a solvent of the mixed solution is concentrated in heating, at low pressure if required, and slowly cooled to room temperature to boil out and precipitate, (3) the suspension is filtered and dried to prepare the salt. ^ EFFECT: what is produced is the new aliskiren and orotic acid salt showing high physical and chemical stability. ^ 10 cl, 3 tbl, 2 ex |
