| 摘要 |
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to novel substituted pyrimidine derivatives, possessing properties of inhibiting activity of receptor of kinase insertion domain (KDR), or their pharmaceutically acceptable salts. In formula (1): each of X and Y independently represent O, NR, where R represents H; Z represents CR', where R' represents H or halogen; V, U and T together represent or each of R1, R2, R3, R4 and R6 independently represent H, halogen, cyano, C1-10alkyl; R5 values are given in the invention formula; R7 represents C1-10alkyl. ^ EFFECT: invention also relates to method of treating angiogenesis-associated disorder such as cancer or age-related macular degeneration. ^ 16 cl, 318 ex |
