MODIFIED ANTIBODY WITH ENHANCED BIOLOGICAL ACTIVITY

摘要

PROBLEM TO BE SOLVED: To provide methods for enhancing effector activities of antibodies.

SOLUTION: Modified antibodies in which Fc domains are linked in tandem to the C terminus of the heavy chain, and modified antibodies in which Fc domains are linked in tandem via spacers are produced; and the affinity for Fc receptors, CDC activity, and ADCC activity are measured. It has been reported that the CDC activity is not enhanced even if multiple Fcs are linked. However the modified antibodies exhibit the enhanced ADCC activity. The methods enable provision of antibody pharmaceuticals having a marked therapeutic effect.

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