PHARMACEUTICAL COMPOSITION INCLUDING POLYMER MICROSPHERE CONTAINING OLANZAPINE AS ACTIVE INGREDIENT

摘要

The present invention relates to a pharmaceutical composition including a polymer microsphere that contains olanzapine as an active ingredient, and more particularly, to a pharmaceutical composition including a polymer microsphere containing olanzapine as an active ingredient, for treating or preventing a disease or a symptom thereof, the disease selected from a group comprised of schizophrenia and related mental illnesses, bipolar mania, bipolar disorder, seizure, obsessive/compulsive disorder, generalized anxiety disorder, post traumatic distress syndrome, extreme shyness, diabetic nerve pain, and depression, and to a method for preventing or treating, and usage thereof, and the pharmaceutical composition prepared by a method comprising the following steps: mixing a water insoluble organic solvent and a dispersion solvent; preparing a dispersion by mixing a polymer compound, olanzapine, and the water insoluble organic solvent; manufacturing an emulsion by mixing the dispersion with the dispersion solvent in which the water insoluble organic solvent while maintaining the temperature of the emulsion between 0°C to 10°C; and eliminating the water insoluble organic solvent from the emulsion by adding a base or an acid while maintaining the emulsion between 0°C to 10°C. The method for preparing of the present invention does not involve the existing steps of solvent evaporation or solvent extraction, uses little amount of water thereby minimizing waste water generation, while allowing for preparing the polymer microsphere including olanzapine in a swift and simple manner, maintains a low density of solvent remnants inside the polymer microsphere, and is effective for manufacturing sustained-release medicine including anastrozole, as the speed of releasing anastrozole in the body can be adjusted.