| 发明名称 |
USE OF INHIBITORS OF BRUTON'S TYROSINE KINASE (BTK) |
| 摘要 |
Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.
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| 申请公布号 |
US2012183535(A1) |
申请公布日期 |
2012.07.19 |
| 申请号 |
US201113340522 |
申请日期 |
2011.12.29 |
| 申请人 |
BUGGY JOSEPH J.;ELIAS LAURENCE;FYFE GWEN;HEDRICK ERIC;LOURY DAVID J.;MODY TARAK D.;PHARMACYCLICS, INC. |
发明人 |
BUGGY JOSEPH J.;ELIAS LAURENCE;FYFE GWEN;HEDRICK ERIC;LOURY DAVID J.;MODY TARAK D. |
| 分类号 |
A61K31/519;A61K31/664;A61K31/69;A61K31/704;A61K31/7068;A61K31/7076;A61K39/395;A61P35/00 |
主分类号 |
A61K31/519 |
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