发明名称 |
METHODS AND COMPOSITIONS FOR TREATING CANCER AND RELATED METHODS |
摘要 |
<p>The present invention relates to anti-cancer therapeutics. In certain aspects, cancers are treated with a combination of an anti-EGFR agent and an agent that increases the activity of the KLF6 tumor suppressor gene and/or an agent that increases activity of the FOXO1 tumor suppressor gene. In a preferred aspect, the anti-EGFR agent erlotinib a tricyclic agent compound, are used in combination to treat non-small cell lung cancer in a patient with primary or acquired drug resistance to erlotinib, and wherein the tricyclic agent is administered in an amount that does not lead to a substantial central nervous system effect. In additional aspects, the invention relates to compositions and kits useful for treating cancers, methods for screening for compounds that enhance the activity of anti-EGFR agent, and methods for determining whether a patient will respond to anti-EGFR therapy.</p> |
申请公布号 |
WO2012097054(A1) |
申请公布日期 |
2012.07.19 |
申请号 |
WO2012US20922 |
申请日期 |
2012.01.11 |
申请人 |
MOUNT SINAI SCHOOL OF MEDICINE;NARLA, GOUTHAM;OHLMEYER, MICHAEL;GALSKY, MATTHEW DAVID |
发明人 |
NARLA, GOUTHAM;OHLMEYER, MICHAEL;GALSKY, MATTHEW DAVID |
分类号 |
A61K31/496;A61K31/57;A61K45/06;A61P35/00 |
主分类号 |
A61K31/496 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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