发明名称 |
HETEROCYLCIC DERIVATIVES AS INHIBITORS OF GLUTAMINYL CYCLASE |
摘要 |
The invention relates to novel pyrrolidine derivatives of formula (I): wherein R1, R2 and R3 are as defined herein, as inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5). QC catalyzes the intramolecular cyclization of N-terminal glutamine residues into pyroglutamic acid (5-oxo-prolyl, pGlu*) under liberation of ammonia and the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid under liberation of water. |
申请公布号 |
EP2475428(A1) |
申请公布日期 |
2012.07.18 |
申请号 |
EP20100751952 |
申请日期 |
2010.09.13 |
申请人 |
PROBIODRUG AG |
发明人 |
HEISER, ULRICH;SOMMER, ROBERT;RAMSBECK, DANIEL;MEYER, ANTJE;HOFFMANN, TORSTEN;BOEHME, LIVIA;DEMUTH, HANS-ULRICH |
分类号 |
A61P25/00;A61K31/4184;A61K31/437;A61P25/28;C07D403/14;C07D405/14;C07D413/04;C07D413/14;C07D417/14;C07D471/04 |
主分类号 |
A61P25/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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