发明名称 |
S-5-SUBSTITUENT-N-2'-(THIOPHENE-2-YL)ETHYL-TETRALIN-2-AMINE OR CHIRAL ACID SALTS THEREOF AND USE FOR PREPARING ROTIGOTINE |
摘要 |
The chiral compound S-5-substituted-N-2-(thienyl-2-yl-)ethyl-tetralin-2-amine or its chiral acid salts and preparation method thereof are disclosed, and the method for preparing Rotigotine by using the chiral compound is also disclosed. Racemic 5-substituted-N-2'-(thien-2-yl-)ethyl-tetralin-2-amine (compound 1 ) is resolved by using a conventional chiral acid to obtain an optically pure chiral acid salt of S-5-substituted-N,2'-(thien-2-yl-)ethyl-tetralin-2-amine, which is then dissociated to obtain S-5-substituted-N-2'-(thien-2-yl-)ethyl-tetralin-2-amine (compound 2 ). The compound 2 or chiral acid salt thereof is alkylated and deprotected to produce rotigotine (compound 5 ). |
申请公布号 |
EP2476676(A1) |
申请公布日期 |
2012.07.18 |
申请号 |
EP20100813240 |
申请日期 |
2010.09.07 |
申请人 |
2Y-CHEM, LTD. |
发明人 |
HE, XUNGUI;GUO, JIANPING;WANG, YANLING;TANG, WENSHENG;ZHANG, XINGZHONG;WANG, XUEZHANG;WANG, YUAN |
分类号 |
C07D333/20;C07B57/00 |
主分类号 |
C07D333/20 |
代理机构 |
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代理人 |
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地址 |
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