发明名称 |
AN ISOLATED MONOPHOSPHORYLATED PEPTIDE DERIVED FROM HUMAN ALPHA-ENOLASE USEFUL FOR DIAGNOSIS AND TREATMENT OF PANCREATIC ADENOCARCINOMA, ANTIBODIES DIRECTED AGAINST THE SAID MONOPHOSPHORYLATED PEPTIDE, AND USES THEREOF |
摘要 |
<p>An isolated peptide of 12-20 amino acids in length comprising the amino acid sequence SEQ ID NO:1, wherein the serine residue (S) at position 8 of SEQ ID NO:1 is phosphorylated, is provided. Also provided is a human monophosphorylated alpha-enolase isoform wherein the serine residue (S) at position 419 of the human alpha-enolase amino acid sequence (SEQ ID NO:2) is phosphorylated and in which other post-translational modifications may be present. Further provided are antibodies capable of specifically binding the peptide and/or the isoform of the invention. The peptide, the isoform and the antibodies of the invention may be used in the diagnosis and/or amelioration and/or treatment of pancreatic adenocarcinoma.</p> |
申请公布号 |
EP2475685(A1) |
申请公布日期 |
2012.07.18 |
申请号 |
EP20100763018 |
申请日期 |
2010.09.09 |
申请人 |
NOVELLI, FRANCESCO;NATIMAB THERAPEUTICS S.R.L. |
发明人 |
NOVELLI, FRANCESCO;TOMAINO, BARBARA;CAPPELLO, PAOLA |
分类号 |
C07K16/40;C12N9/88;G01N33/574 |
主分类号 |
C07K16/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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