发明名称 |
PROCESS FOR THE MANUFACTURE OF MICROSPHERES OR MICROCAPSULES |
摘要 |
<p>A process for the manufacture of free-flowing uniformly sized micro spheres for the sustained release of therapeutically active ingredient comprising: a) preparing a first dispersed phase comprising a therapeutically active ingredient, a biodegradable polymer and an organic solvent; b) mixing the first dispersed phase with a aqueous phase to form an emulsion; c) spraying the emulsion into a vessel (20) equipped with organic solvent removal means; d) passing the suspension of micro spheres through screens and collecting a fractionated size of the microspheres on the surface of the screens; e) drying the microspheres wherein steps a to e are carried out without manual intervention, in equipment connected in series, substantially unexposed to the environment;</p> |
申请公布号 |
EP1853228(A4) |
申请公布日期 |
2012.07.18 |
申请号 |
EP20060780513 |
申请日期 |
2006.03.01 |
申请人 |
SUN PHARMA ADVANCED RESEARCH COMPANY LTD |
发明人 |
KHOPADE, AJAY;GEORGE, ALEX;BHOWMICK, SUBHAS BALARAM |
分类号 |
A61K9/16 |
主分类号 |
A61K9/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|