| 发明名称 |
CIS-2,4,5-TRIPHENYL-IMIDAZOLINES AND THEIR USE IN THE TREATMENT OF TUMORS |
| 摘要 |
The present invention provides compounds according to formula I and formula II and pharmaceutically acceptable salts ad esters thereof, having the designations provides herein and which inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity. Formula (I).
|
| 申请公布号 |
CA2469187(C) |
申请公布日期 |
2012.07.17 |
| 申请号 |
CA20022469187 |
申请日期 |
2002.12.09 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
KONG, NORMAN;LIU, EMILY AIJUN;VU, BINH THANH |
| 分类号 |
C07D413/06;A61K31/4164;A61K31/422;A61K31/454;A61K31/4545;A61K31/496;A61K31/501;A61K31/5377;A61P35/00;A61P43/00;C07D233/22;C07D233/24;C07D233/26;C07D401/06;C07D403/06;C07D403/12;C07D405/04;C07D405/06;C07D405/10;C07D409/06;C07D521/00 |
主分类号 |
C07D413/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
