发明名称 |
Use of dimiracetam in the treatment of chronic pain |
摘要 |
The use of dimiracetam in the treatment of chronic pain is disclosed. At doses higher than those previously disclosed in relation with its cognition enhancing activity (i.e. amelioration of learning and memory), dimiracetam was able to completely revert hyperalgesia or allodynia associated with several animal models of chronic pain. Dimiracetam showed high activity in iatrogenic neuropathies associated with antiviral and chemotherapeutic drug treatments and in painful conditions caused by osteoarthritis. In addition, dimiracetam was devoid of toxicity even at doses 10-fold higher than the highest therapeutic dose. The possibility of treating such debilitating pathologies with a highly effective and essentially non-toxic compound is therefore disclosed.
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申请公布号 |
US8222241(B2) |
申请公布日期 |
2012.07.17 |
申请号 |
US201113166088 |
申请日期 |
2011.06.22 |
申请人 |
FARINA CARLO;GHELARDINI CARLA;PETRILLO PAOLA;NEUROTUNE AG |
发明人 |
FARINA CARLO;GHELARDINI CARLA;PETRILLO PAOLA |
分类号 |
A61K31/44;A61K31/40;A61P23/00 |
主分类号 |
A61K31/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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