发明名称 |
METHOD FOR PREPARING [18F]FALLYPRIDE WITH LOW BASE CONCENTRATION |
摘要 |
A method for preparing [18F]fallypride is disclosed, which comprises a first step for trapping a fluorine-18 to a polymer ion exchange cartridge; a second step for extraction of fluorine-18 by inputting low base concentrations: 5.0˜25 μL of 40% TBAHCO3 or K2.2.2./K2CO3 (5˜25 mg/0.5˜3.0 mg) as a phase-transfer catalyst in a mixture of alcohol/water (1.0/0.2 (v/v)) or alcohol as a solvent into the polymer ion exchange cartridge trapped by the fluorine-18; a third step for preparing a [18F]fallypride product by removing the solvent from the trapped fluorine-18, by inputting tosylate precursor in CH3CN as a solvent into a reactor and by reacting the same for 5˜35 minutes at 50˜120° C.; and a fourth step for preparing a pure [18F]fallypride by purifying the prepared [18F]fallypride product. |
申请公布号 |
US2012178920(A1) |
申请公布日期 |
2012.07.12 |
申请号 |
US201013395841 |
申请日期 |
2010.03.04 |
申请人 |
KIM SANG EUN;LEE BYUNG CHUL;MOON BYUNG SEOK;KIM YU KYEONG;SNU R&DB FOUNDATION |
发明人 |
KIM SANG EUN;LEE BYUNG CHUL;MOON BYUNG SEOK;KIM YU KYEONG |
分类号 |
C07D207/09;C07C253/30;C07D451/02;C07H19/052 |
主分类号 |
C07D207/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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