发明名称 |
METHODS FOR ENHANCING THE DELIVERY OF GENE-TRANSDUCED CELLS |
摘要 |
The present invention provides novel methods for enhancing the delivery of transduced cells to a subject, which include both methods of selecting for transduced cells and methods of enhancing the reconstitution by transduced cells in a transplant recipient. The present invention further provides transfer vectors, including lentiviral vectors, useful in practicing the methods of the present invention. The methods and vectors of the present invention may be used in gene therapy of a variety of diseases and disorders, including but not limited to hematological diseases and disorders. |
申请公布号 |
WO2012094193(A2) |
申请公布日期 |
2012.07.12 |
申请号 |
WO2011US67347 |
申请日期 |
2011.12.27 |
申请人 |
BLUEBIRD BIO, INC.;DOWN, JULIAN DAVID;LEBOULCH, PHILIPPE LOUIS |
发明人 |
DOWN, JULIAN DAVID;LEBOULCH, PHILIPPE LOUIS |
分类号 |
C12N5/074;A61K48/00;C12N5/02;C12N5/0735;C12N5/10;C12N15/86 |
主分类号 |
C12N5/074 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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