Novel heterocyclic NF-kappaB inhibitors

摘要

The present invention relates to compounds of the general formula (I) and salts and physiologically functional derivatives thereof, (I) wherein Ris independently hydrogen, alkyl, cycloalkyl, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl or substituted arylalkyl; R is independently -NRR, (II) or (III) R is independently alkyl, cycloalkyl, alkoxy, alkylamine, -OH, -SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl, R is independently alkyl, cycloalkyl, alkoxy, alkylamine, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; Ris independently H, COR, C0R, SOR, SOR, SOR, alkyl, cycloalkyl, alkoxy, -NH, alkylamine, -NRCOR, halogen, -OH, -SH, alkylthio, hydroxyalkyl, haloalkyl, haloalkyloxy, aryl or heteroaryl; Ris independently H, alkyl, cycloalkyl, -NH, alkylamine, aryl or heteroaryl; R is independently H, alkyl, cycloalkyl, alkoxy, -OH, -SH, alkylthio, hydroxyalkyl, aryl, or heteroaryl; p is 0, or l; q is 0, or 1; X is CO, or SO.