发明名称 |
METHOD FOR SUPPRESSING ESTERIFICATION OF PHARMACEUTICAL COMPOSITION |
摘要 |
Disclosed are a pharmaceutical composition for external application, an adhesive skin patch and others which are improved in a drug release property, transdermal absorbability and stability of a pharmacologically active ingredient contained therein and can reduce the aggravation of irritation to the skin. Specifically disclosed is an adhesive skin patch comprising a support and an adhesive layer laminated on the support, wherein the adhesive layer contains a pharmaceutical composition for external application. The pharmaceutical composition for external application comprises a pharmacologically active ingredient, an auxiliary component and a pyrrolidone compound, wherein one of the pharmacologically active ingredient and the auxiliary component has a carboxylate group in the molecule and the other has a hydroxy group in the molecule. Preferably, the adhesive layer further comprises a hydrogenated oil. |
申请公布号 |
US2012178788(A1) |
申请公布日期 |
2012.07.12 |
申请号 |
US201213420991 |
申请日期 |
2012.03.15 |
申请人 |
KAWAMURA NAOHISA;SAITOH TAKASHI;TSUCHIYA JUNKO;SUGAYA CHIE;NIPRO PATCH CO., LTD |
发明人 |
KAWAMURA NAOHISA;SAITOH TAKASHI;TSUCHIYA JUNKO;SUGAYA CHIE |
分类号 |
A61K31/405;A61K31/137;A61K31/192;A61K31/196 |
主分类号 |
A61K31/405 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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