发明名称 |
METHODS FOR TREATING FRONTOTEMPORAL LOBAR DEGENERATION WITH UBIQUITINATED INCLUSIONS (FTLD-U) |
摘要 |
Methods for rescuing learning, memory and/or motor function deficits associated with frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) are disclosed. The method comprises: a) administering to an animal having FTLD-U a therapeutically effective amount of an autophagy inducer; b) causing a decrease in the amount of ubiquitinated TDP-43 aggregation forms in the brain of the animal; and c) causing an improvement of the learning, memory capacities and/or motor function of the animal. |
申请公布号 |
US2012178775(A1) |
申请公布日期 |
2012.07.12 |
申请号 |
US201213343686 |
申请日期 |
2012.01.04 |
申请人 |
SHEN CHE-KUN JAMES;TSAI KUEN-JER;ACADEMIA SINICA |
发明人 |
SHEN CHE-KUN JAMES;TSAI KUEN-JER |
分类号 |
A61K31/439;A61P25/00 |
主分类号 |
A61K31/439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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