| 摘要 |
The present invention relates to an industrial method for preparing an aqueous suspension of an anti-inflammatory steroidal agent including a dispersant, a suspending agent, and one or more carriers selected from within the group consisting of antimicrobial agents, chelating agents, iso-osmotic agents, antioxidant agents, and the mixtures thereof, characterized in that it includes the following consecutive steps: a) preparing, in a reactor (1), a dispersion including water, said one or more carriers, the dispersant which is a hydrophilic non-ionic surfactant, and the anti-inflammatory steroidal agent in the form of particles; b) adding, to the dispersion obtained as a result of step a) and in said reactor (1), the suspension agent as is; and c) if necessary, diluting by adding water into said reactor (1), and/or adjusting the pH of said suspension obtained as a result of step b), and recovering the aqueous suspension. The anti-inflammatory steroidal agent is advantageously selected from within the group consisting of triamcinolone acetonide and mometasone furuoate monohydrate, and is preferably triamcinolone acetonide. |
