发明名称 |
NEW SACCHARIDE MIMICS AND THEIR USE AS INHIBITORS OF ANGIOGENESIS AND METASTASIS FORMATION |
摘要 |
The present invention relates to saccharide mimics which show a better biological activity at low concentrations as known saccharide mimics in inhibiting angiogenesis and inhibiting formation of metastasis by inhibiting adhesion and/or migration of human cancer cells, particularly in concentrations lower than 5 mM, and to pharmaceutical compositions comprising these saccharide mimics. The compounds of the present invention are useful as mimics of cell surface structures and, thus, for influencing cell-cell and cell-extracellular (ECM) interactions, which are controlled by bonds between protein-protein, saccharide-saccharide or saccharide-lectin on the cell-surface. |
申请公布号 |
WO2012093091(A2) |
申请公布日期 |
2012.07.12 |
申请号 |
WO2012EP00040 |
申请日期 |
2012.01.05 |
申请人 |
DEUTSCHES KREBSFORSCHUNGSZENTRUM;SCHWARTZ-ALBIEZ, REINHARD;MARANO, GRAZIA;FREI, EVA;FRANK, MARTIN;MEISTER, BETINA |
发明人 |
SCHWARTZ-ALBIEZ, REINHARD;MARANO, GRAZIA;FREI, EVA;FRANK, MARTIN;MEISTER, BETINA |
分类号 |
C07H15/26;A61K31/7048;A61P35/04 |
主分类号 |
C07H15/26 |
代理机构 |
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