| 发明名称 |
FAMILY OF PFKFB3 INHIBITORS WITH ANTI-NEOPLASTIC ACTIVITIES |
| 摘要 |
A methods and compounds for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer, and screening compounds to determine their ability to inhibit PFKFB3. |
| 申请公布号 |
US2012177749(A1) |
申请公布日期 |
2012.07.12 |
| 申请号 |
US201113307552 |
申请日期 |
2011.11.30 |
| 申请人 |
TAPOLSKY GILLES;CHAND POORAN;TRENT JOHN O.;TELANG SUCHETA;CLEM BRIAN F.;CHESNEY JASON A.;UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.;ADVANCED CANCER THERAPEUTICS, LLC |
发明人 |
TAPOLSKY GILLES;CHAND POORAN;TRENT JOHN O.;TELANG SUCHETA;CLEM BRIAN F.;CHESNEY JASON A. |
| 分类号 |
A61K31/4709;A61K31/47;A61K33/24;A61P35/00;C07D215/14;C07D401/06;C12N5/02 |
主分类号 |
A61K31/4709 |
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