| 发明名称 |
ARTIFICIAL LOW-DENSITY LIPOPROTEIN CARRIER FOR TRANSPORT OF SUBSTANCE ACROSS BLOOD-BRAIN BARRIER |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a highly efficient artificial low-density lipoprotein (LDL) carrier system for the targeted delivery of therapeutic agents across the blood-brain barrier (BBB). <P>SOLUTION: This invention relates to artificial LDL particles comprised of three lipid elements e.g. phosphatidyl choline, fatty-acyl-cholesterol esters, and at least one apolipoprotein. The present invention further relates to compositions, methods and kits comprising artificial LDL particles for targeting drugs to and across the BBB for the prevention and treatment of brain diseases. <P>COPYRIGHT: (C)2012,JPO&INPIT |
| 申请公布号 |
JP2012131799(A) |
申请公布日期 |
2012.07.12 |
| 申请号 |
JP20120021053 |
申请日期 |
2012.02.02 |
| 申请人 |
BLANCHETTE ROCKEFELLER NEUROSCIENCES INST |
发明人 |
NELSON THOMAS J;QUATTRONE ALESSANDRO;ALKON DANIEL L |
| 分类号 |
A61K47/42;A61K9/10;A61K9/127;A61K31/197;A61K31/65;A61K31/704;A61K38/00;A61K45/00;A61K47/24;A61K47/28;A61K47/48;A61P5/00;A61P25/00;A61P25/16;A61P25/28;A61P31/04;A61P31/10;A61P31/12;A61P35/00;A61P43/00 |
主分类号 |
A61K47/42 |
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