发明名称 |
COMPOSITIONS AND METHODS FOR RIBONUCLEASE-BASED THERAPIES |
摘要 |
The present invention relates generally to conjugates of human ribonucleases and water-soluble polymers, compositions comprising the conjugates and methods of using the same. In particular, the present invention provides conjugates of human ribonucleases and one or more water-soluble polymer compositions (e.g., to increase serum half-life and a pharmacokinetic profile, in vivo biological activity, stability, and/or reduce host immune response to the protein in vivo) as well as methods of using the conjugates in the therapy, treatment, and/or prevention of disease (e.g., cancer). |
申请公布号 |
EP2205271(A4) |
申请公布日期 |
2012.07.11 |
申请号 |
EP20080837402 |
申请日期 |
2008.10.08 |
申请人 |
QUINTESSENCE BIOSCIENCES, INC. |
发明人 |
RAINES, RONALD, T.;RUTKOSKI, THOMAS, J.;KINK, JOHN, A.;STRONG, LAURA, E. |
分类号 |
A61K38/46;C12N9/22 |
主分类号 |
A61K38/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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