| 摘要 |
The invention comprises compounds of the general formula <FORM:1001828/C2/1> (wherein R represents a phenyl group, which may be substituted by a C1- 4 alkyl or alkoxy radical, or a benzyl group) and physiologically tolerable acid addition salts thereof, pharmaceutical preparations containing them, and their preparation by (a) reducing phenylacetone in the presence of an amine of the formula (I) <FORM:1001828/C2/2> or reacting phenylacetone with the amine and reducing the product, (b) reacting an amine (I) with a 1-phenyl-2-halopropane or 1 - phenyl - 2-halopropene and hydrogenating the aliphatic double bond (if present) in the product, (c) reacting a halide of the formula <FORM:1001828/C2/3> (wherein Hal represents a halogen atom) with 1-phenyl-2-aminopropane, (d) reducing an aldehyde of the formula <FORM:1001828/C2/4> in the presence of 1-phenyl-2-aminopropane, or reacting the aldehyde with 1-phenyl-2-aminopropane and reducing the product, or (e) reducing an amide of the formula <FORM:1001828/C2/5> optionally followed in each case by acid addition salt formation. The starting materials are prepared by standard methods. The compounds of the invention exhibit heart and blood circulation activity, and may be administered orally or parenterally in the form of pharmaceutical preparations (e.g. tablets, dragees and solutions) containing them together with a carrier. |
