发明名称 |
COMPOSITIONS AND METHODS FOR THE DELIVERY OF OXYGEN |
摘要 |
H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O 2 delivery. The engineered H-NOX proteins comprise mutations that impart altered O 2 or NO ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood O 2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of O 2 is beneficial. |
申请公布号 |
EP2474554(A2) |
申请公布日期 |
2012.07.11 |
申请号 |
EP20110189818 |
申请日期 |
2007.05.21 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CARY, STEPHEN P.L.;BOON, ELIZABETH M.;WEINERT, EMILY;WINGER, JONATHAN A.;MARLETTA, MICHAEL A. |
分类号 |
C07K14/00 |
主分类号 |
C07K14/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|